NCIS, a long-running TV series, has experienced a notable cast turnover. Sasha Alexander left after two seasons due to the demanding schedule, while Cote de Pablo departed in Season 11 citing issues with scripts and character treatment. Michael Weatherly left after 13 seasons feeling burnt out but on good terms, and Jennifer Esposito’s tenure was brief, leaving to care for her ailing mother. Pauley Perrette’s abrupt departure in Season 15 revealed tensions with co-star Mark Harmon, and Emily Wickersham left after Season 18 to focus on family. Maria Bello exited on good terms after her contract ended, and Mark Harmon left after 18 years, possibly due to age-related challenges. The show’s future is uncertain, leaving fans hoping for the return of familiar faces.